Department of Medical Sciences
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Recent Submissions
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Adapting methods of key population programmatic mapping and enumeration to inform HIV prevention programs for adolescent girls and young women
(JMIR Publications, 2018-05-31)Background: Standard programmatic mapping involves identifying locations where key populations meet, profiling of these locations (hotspots) and estimating the key population size. Information gained from this method has ... -
Rationale and design of a multi-center, open-label, randomised clinical trial comparing HIV incidence and contraceptive benefits in women using three commonly-used contraceptive methods (the ECHO study)
(Gates Open Research, 2018-03-13)Background: In vitro, animal, biological and observational clinical studies suggest that some hormonal methods, particularly depot medroxyprogesterone acetate – DMPA, may increase women’s risk of HIV acquisition. DMPA is ... -
CHARACTERIZATION OF ALGAE OIL (OILGAE) AND ITS POTENTIAL AS BIOFUEL IN KENYA
(JAHES, 2012-05)A survey of microalgae biodiversity in three Kenyan Rift valley lakes identified high oil yielding species abundantly distributed naturally. The species were cultured in BBM and BG-11 media to obtain pure clones and ... -
Prevalence of Metabolic Syndrome Among an Urban Population in Kenya
(American Diabetes Association, 2012-01)Developing countries are undergoing an epidemiologic transition accompanied by increasing burden of cardiovascular disease (CVD) linked to urbanization and lifestyle modifications. Metabolic syndrome is a cluster of CVD ... -
Purification and characterization of a midgut lectin-trypsin complex from the tsetse fly Glossina Iongipennis
(Springer-Link, 1995-04)A blood-meal-induced lectin (agglutinin) with proteolytic activity was isolated from midgut extracts ofGlossina longipennis by a two-step procedure involving anion-exchange chromatography. It is a glycoprotein [native ... -
Dual African Origins of Global Aedes aegypti s.l. Populations Revealed by Mitochondrial DNA
(PLOS, 2013-04)Aedes aegypti is the primary global vector to humans of yellow fever and dengue flaviviruses. Over the past 50 years, many population genetic studies have documented large genetic differences among global populations of ... -
MHC-Ig Dimers: The next Frontier in Transplantation Immunology
(International Journal of Biomedical Research, 2015-09)Organ transplantation offers hope to a variety of patients with terminal functioning organs and tissues. This is currently made possible by administration of general immunosuppressive drugs. To date, inducing tolerance to ... -
The Occurrence of Glucose 6 Phosphate Dehydrogenase Deficiency amongst Blood Donors at the Regional Blood Transfusion Centre-Mombasa, Kenya
(Pharmaceutical Society of Kenya, 2018-09)Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is an X-linked hereditary genetic defect that is estimated to affect 400 million people worldwide. This deficiency is associated with hemolytic disorders that may manifest ... -
Occurrence of red blood cell abnormalities in donor blood donated at the regional blood transfusion centre, Mombasa, Kenya
(2023-01)During transfusion, components of blood including red blood cells, platelets and plasma are directly administered into the recipient to treat conditions such as anaemia and haemostatic deficiencies. In most cases, effective ... -
Bone Marrow Transplantation Restores Follicular Maturation and Steroid Hormones Production in a Mouse Model for Primary Ovarian Failure
(PLoS ONE, 2012)Recent studies suggest that bone marrow stem cells (BMSCs) are promising grafts to treat a variety of diseases, including reproductive dysfunction. Primary ovarian failure is characterized by amenorrhea and infertility ... -
Lack of Fetuin-A ( 2-HS-Glycoprotein) Reduces Mammary Tumor Incidence and Prolongs Tumor Latency via the Transforming Growth Factor-Signaling Pathway in a Mouse Model of Breast Cancer
(2015-10-21)The present analyses were done to define the role of fetuin-A (Fet) in mammary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model. We crossed Fet-null mice in the C57BL/6 background with ... -
Spatial Temporal Modelling of Tuberculosis in Kenya Using Small Area Estimation
(International Journal of Science and Research (IJSR), 2015)Tuberculosis (TB) is a disease which continues to be of public health importance, and is characterized with varying distribution across regions depending on socio-economic status, HIV burden and efficiency of the health ...
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