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dc.contributor.authorPaganini, Daniela
dc.contributor.authorUyoga, Mary A
dc.contributor.authorCercamondi, Colin I
dc.contributor.authorMoretti, Diego
dc.contributor.authorMwasi, Edith
dc.contributor.authorSchwab, Clarissa
dc.contributor.authorBechtler, Salome
dc.contributor.authorMutuku, Francis M
dc.contributor.authorLacroix, Christophe
dc.contributor.authorGaletti, Valeria
dc.contributor.authorKaranja, Simon
dc.contributor.authorZimmermann, Michael B
dc.date.accessioned2021-05-11T08:32:50Z
dc.date.available2021-05-11T08:32:50Z
dc.date.issued2017
dc.identifier.issn1020–31
dc.identifier.urihttps://ir.tum.ac.ke/handle/123456789/17359
dc.description.abstractBackground: Whether consumption of prebiotics increases iron absorption in infants is unclear. Objective: We set out to determine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) containing a mixture of ferrous fumarate and sodium iron EDTA (FeFum+ NaFeEDTA) in Kenyan infants. Design: Infants (n = 50; aged 6–14 mo) consumed maize porridge that was fortified with an MNP containing FeFum+NaFeEDTA and 7.5 g galacto-oligosaccharides (GOSs) (Fe+GOS group, n = 22) or the same MNP without GOSs (Fe group, n = 28) each day for 3 wk. Then, on 2 consecutive days, we fed all infants isotopically labeled maize porridge and MNP test meals containing 5 mg Fe as 57FeFum+Na58 FeEDTA or ferrous sulfate (54FeSO4). Iron absorption was measured as the erythrocyte incorporation of stable isotopes. Iron markers, fecal pH, and bacterial groups were assessed at baseline and 3 wk. Com parisons within and between groups were done with the use of mixed effects models. Results: There was a significant group-by-compound interaction on iron absorption (P = 0.011). The median percentages of fractional iron absorption from FeFum+NaFeEDTA and from FeSO4 in the Fe group were 11.6% (IQR: 6.9–19.9%) and 20.3% (IQR: 14.2– 25.7%), respectively, (P , 0.001) and, in the Fe+GOS group, were 18.8% (IQR: 8.3–37.5%) and 25.5% (IQR: 15.1–37.8%), respec tively (P = 0.124). Between groups, iron absorption was greater from the FeFum+NaFeEDTA (P = 0.047) in the Fe+GOS group but not from the FeSO4 (P = 0.653). The relative iron bioavailability from FeFum+NaFeEDTA compared with FeSO4 was higher in the Fe+GOS group than in the Fe group (88% compared with 63%; P = 0.006). There was a significant time-by-group interaction on Bifido bacterium spp. (P = 0.008) and Lactobacillus/Pediococcus/Leuconostoc spp. (P = 0.018); Lactobacillus/Pediococcus/Leuconostoc spp. decreased in the Fe group (P = 0.013), and there was a nonsignificant trend toward higher Bifidobacterium spp. in the Fe+GOS group (P = 0.099). At 3 wk, iron absorption was negatively correlated with fecal pH (P , 0.001) and positively correlated with Lactobacillus/Pediococcus/ Leuconostoc spp. (P = 0.001). Conclusion: GOS consumption by nfants increased iron absorption by 62% from an MNP containing FeFum+NaFeEDTA, thereby possibly reflecting greater colonic iron absorption. This trial was registered at clinicaltrials.gov as NCT02666417. Am J Clin Nutr 2017;en_US
dc.language.isoenen_US
dc.publisherAmerican Society for Nutritionen_US
dc.relation.ispartofseries;106
dc.subjectanemiaen_US
dc.subjectgalacto-oligosaccharidesen_US
dc.subjectGOSen_US
dc.subjectinfantsen_US
dc.subjectiron deficiencyen_US
dc.subjectiron absorptionen_US
dc.subjectKenyaen_US
dc.subjectmicronutrient powderen_US
dc.subjectprebioticsen_US
dc.subjectstable isotopesen_US
dc.titleConsumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infantsen_US
dc.typeArticleen_US


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