Show simple item record

dc.contributor.authorVu, David M.
dc.contributor.authorMalhotra, Indu
dc.contributor.authorKing, Charles Hc
dc.contributor.authorMutuku, Francis
dc.contributor.authorLaBeaud, Desiree
dc.date.accessioned2021-05-11T11:02:10Z
dc.date.available2021-05-11T11:02:10Z
dc.date.issued2017
dc.identifier.urihttps://ir.tum.ac.ke/handle/123456789/17367
dc.description.abstractMany factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected from a parent study of 576 pregnant Ke-nyan women four groups of women with term deliveries ( 37 weeks), including un-infected women (n 30) and women with solo infections with malaria (n 30), hookworm (n 30), or schistosomiasis (n 10). Maternal plasma at delivery and in fant cord blood were tested via multiplex fluorescent bead assay for IgG against 10 pneumococcal serotypes (PnPs 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F), diphtheria toxoid, and Haemophilus influenzae type B. Infants born to mothers with prenatal malaria, hookworm, or Schistosoma haematobium infections were associated with a significantly reduced ratio of maternal to infant cord blood antibody concentration for Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, and 18C compared to in fants of uninfected mothers. Anti-diphtheria toxoid and anti-H. influenzae type B IgG ratios were not significantly different among infection groups. Prenatal parasitic in fections decrease the transfer of maternal IgG antibodies to infants for several sero types of S. pneumoniae.en_US
dc.language.isoenen_US
dc.publisherAMERICAN SOCIETY FOR MICROBIOLOGYen_US
dc.relation.ispartofseries;Volume 24
dc.subjecthumoral immunityen_US
dc.subjectparasitesen_US
dc.subjectplacental antibody transferen_US
dc.subjectpregnancyen_US
dc.titleParasitic Infections in Pregnancy Decrease Placental Transfer of Antipneumococcus Antibodiesen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record