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dc.contributor.authorLaBeaud, A. Desiree
dc.contributor.authorBanda, Tamara
dc.contributor.authorBrichard, Julie
dc.contributor.authorMuchiri, Eric M
dc.contributor.authorMungai, Peter L
dc.contributor.authorMutuku, Francis M
dc.contributor.authorBorland, Erin
dc.contributor.authorGildengorin, Ginny
dc.contributor.authorPfeil, Sarah
dc.contributor.authorTeng, Crystal Y
dc.contributor.authorLong, Kristin
dc.contributor.authorHeise, Mark
dc.contributor.authorPowers, Ann M
dc.contributor.authorKitron, Uriel
dc.contributor.authorKing, Charles H
dc.date.accessioned2021-06-09T13:02:54Z
dc.date.available2021-06-09T13:02:54Z
dc.date.issued2014-11-23
dc.identifier.urihttps://ir.tum.ac.ke/handle/123456789/17425
dc.description.abstractChikungunya virus (CHIKV) and o’nyong nyong virus (ONNV) are mosquito-borne alphaviruses endemic in East Africa that cause acute febrile illness and arthritis. The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors. Demographic and exposure questionnaires were administered to 1,848 participants recruited from two village clusters (Milalani-Nganja and Vuga) in 2009. Sera were tested for alphavirus exposure using standardized CHIKV IgG ELISA protocols and confirmed with plaque reduction neutralization tests (PRNT). Logistic regression models were used to determine the variables associated with seropositivity. Weighted K test for global clustering of houses with alphavirus positive participants was performed for distance ranges of 50–1,000 meters, and G* statistic and kernel density mapping were used to identify locations of higher seroprevalence. 486 (26%) participants were seropositive by IgG ELISA. Of 443 PRNT confirmed positives, 25 samples (6%) were CHIKV+, 250 samples (56%) were ONNV+, and 168 samples (38%) had high titers for both. Age was significantly associated with seropositivity (OR 1.01 per year, 95% C.I. 1.00–1.01); however, younger adults were more likely to be seropositive than older adults. Males were less likely to be seropositive (p<0.05; OR 0.79, 95% C.I.0.64–0.97). Adults who owned a bicycle (p<0.05; OR 1.37, 95% C.I. 1.00–1.85) or motor vehicle (p<0.05; OR 4.64, 95% C.I. 1.19–18.05) were more likely to be seropositive. Spatial analysis demonstrated hotspots of transmission within each village and clustering among local households in Milalani-Nganja, peaking at the 200-–00m range. Alphavirus exposure, particularly ONNV exposure, is common in coastal Kenya with ongoing interepidemic transmission of both ONNV and CHIKV. Women and adults were more likely to be seropositive. Household location may be a defining factor for the ecology of alphavirus transmission in this regionen_US
dc.language.isoenen_US
dc.publisherPLOS neglected tropical diseasesen_US
dc.subjectvirusesen_US
dc.subjectCHIKVen_US
dc.subjectONNVen_US
dc.titleHigh Rates of O’Nyong Nyong and Chikungunya Virus Transmission in Coastal Kenyaen_US
dc.typeArticleen_US


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