Department of Medical Sciences
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Recent Submissions
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Males’ Awareness of Female and Male Contraception Methods, Information, Outreach, and Acquisition Locations in Abidjan, Côte d’Ivoire, Nairobi, Kenya, and Lagos, Nigeria
(Elsevier, 2022-03-16)Purpose: The aim of this study is to describe modern female and male method awareness, information sources, outreach exposures, and acquisition source awareness among young men aged 15-24 by sexual behavior status in ... -
Vernoa hildebranditii, Acacia stuhlmannii and Moringa oleifera Leaf and Root-bark Extracts Exhibit Antimicrobial Effects on Escherichia coli and Staphylococcus aureus Bacteria
(2020-12)Infectious diseases are the main causes of morbidity and mortality worldwide. There is increasing concern of indiscriminate use of antibiotics and incidences of multiple antibiotic resistances in human pathogens. The ... -
A Human-Mouse Hybrid HLA-A2-IG Dimer Inhibits the Proliferation of CD4+T Cells In Vitro
(Multidisciplinary Journal of TUM, 2020)Currently, general immunosuppressive drugs are used to maintain tolerance to allografts. However, these drugs have a major drawback of rendering the patient susceptible to infections and other side effects like malignancy ... -
Rationale and design of a multi-center, open-label, randomised clinical trial comparing HIV incidence and contraceptive benefits in women using three commonly-used contraceptive methods (the ECHO study) [version 1; peer review: 2 approved]
(Gates foundation, 2017-12-29)Background: In vitro, animal, biological and observational clinical studies suggest that some hormonal methods, particularly depot medroxyprogesterone acetate – DMPA, may increase women’s risk of HIV acquisition. DMPA is ... -
Malaria and Chikungunya Detected Using Molecular Diagnostics Among Febrile Kenyan Children
(Oxford University Press, 2017-01)In sub-Saharan Africa, malaria is frequently over diagnosed as the cause of an undifferentiated febrile illness, whereas arboviral illnesses are presumed to be underdiagnosed. Sera from 385 febrile Kenyan children, who ... -
Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya
(Malaria Journal, 2020)Prevention and treatment of malaria during pregnancy is crucial in dealing with maternal mortality and adverse fetal outcomes. The World Health Organization recommendation to treat all pregnant women with sulfadox ... -
EMBRYONAL RHABDOMYOSARCOMA WITH UTERINE INVERSION: CASE REPORT
(East African Medical Journal, 2006-03)Presented here is a 16 year old nulliparous girl who had embryonal rhabdomyosarcoma causing uterine inversion. She had been referred with a one year history of continuous vaginal bleeding and vaginal swelling. Histology ... -
PATTERNS IN MATERNAL MORTALITY FOLLOWING THE IMPLEMENTATION OF A FREE MATERNAL HEALTH CARE POLICY IN KENYAN PUBLIC HEALTH FACILITIES
(2017)Background: Reduction of pregnancy related mortalities remains one of the greatest health challenges globally. For a long time, low utilization of maternal health care services has been attributed to the unaffordability ... -
High Dengue Burden and Circulation of 4 Virus Serotypes among Children with Undifferentiated Fever, Kenya, 2014–2017
(: Stanford University School of Medicine, 2014)ittle is known about the extent and serotypes of den gue viruses circulating in Africa. We evaluated the pres ence of dengue viremia during 4 years of surveillance (2014–2017) among children with febrile illness in Ke ... -
Unrecognized Dengue Virus Infections in Children, Western Kenya, 2014–2015
(Stanford University School of Medicine, 2014)We detected a cluster of dengue virus infections in children in Kenya during July 2014–June 2015. Most cases were serotype 1, but we detected all 4 serotypes, including co-infections with 2 serotypes. Our findings ... -
Early Childhood Anemia in a Birth Cohort in Coastal Kenya: Links to Infection and Nutrition
(The American Society of Tropical Medicine and Hygiene, 2019)Anemia is known to impact a child’s growth and development, but not all anemia are caused by iron deficiency, and the CDC and WHO have emphasized investigating other contributors to anemia. This cross-sectional sub study ... -
Trends in contraceptive prevalence rates in sub-Saharan Africa since the 2012 London Summit on Family Planning: results from repeated cross-sectional surveys
(The Lancet Global Health, 2019-07)The Family Planning 2020 (FP2020) initiative, launched at the 2012 London Summit on Family Planning, aims to enable 120 million additional women to use modern contraceptive methods by 2020 in the world’s 69 poorest countries. ... -
Bone Marrow Transplantation Restores Follicular Maturation and Steroid Hormones Production in a Mouse Model for Primary Ovarian Failure
(PLoS ONE, 2012)Recent studies suggest that bone marrow stem cells (BMSCs) are promising grafts to treat a variety of diseases, including reproductive dysfunction. Primary ovarian failure is characterized by amenorrhea and infertility ... -
Lack of Fetuin-A ( 2-HS-Glycoprotein) Reduces Mammary Tumor Incidence and Prolongs Tumor Latency via the Transforming Growth Factor-Signaling Pathway in a Mouse Model of Breast Cancer
(2015-10-21)The present analyses were done to define the role of fetuin-A (Fet) in mammary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model. We crossed Fet-null mice in the C57BL/6 background with ... -
Spatial Temporal Modelling of Tuberculosis in Kenya Using Small Area Estimation
(International Journal of Science and Research (IJSR), 2015)Tuberculosis (TB) is a disease which continues to be of public health importance, and is characterized with varying distribution across regions depending on socio-economic status, HIV burden and efficiency of the health ...
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