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dc.contributor.authorMaranga, Innocent O
dc.contributor.authorHampson, Lynne
dc.contributor.authorOliver, Anthony W.
dc.contributor.authorGamal, Anas
dc.contributor.authorGichangi, Peter
dc.contributor.authorOpiyo, Anselmy
dc.contributor.authorHolland, Catharine M.
dc.contributor.authorHampson, Ian N.
dc.date.accessioned2024-02-16T11:36:28Z
dc.date.available2024-02-16T11:36:28Z
dc.date.issued2023
dc.identifier.citationMaranga, I. O., Hampson, L., Oliver, A. W., Gamal, A., Gichangi, P., Opiyo, A., ... & Hampson, I. N. (2013). Analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in Kenya. PloS one, 8(10), e78411.en_US
dc.identifier.urihttp://ir.tum.ac.ke/handle/123456789/17395
dc.descriptionother:doi:10.1371/journal.pone.0078411en_US
dc.description.abstractBackground: In contrast to the developed nations, invasive cervical cancer (ICC) is the most common womens malignancy in Kenya and many other locations in sub-Saharan Africa. However, studies on survival from this disease in this area of the world are severely restricted by lack of patient follow-up. We now report a prospective cohort study of ICC in Kenyan women analysing factors affecting tumour response and overall survival in patients undergoing radiotherapy. Methods and Findings: Between 2008 and 2010, 355 patients with histologically confirmed ICC were recruited at the Departments of Gynaecology and Radiotherapy at Kenyatta National Hospital (KNH). Structured questionnaires were completed recording socio-demographics, tumour response and overall survival following treatment with combinations of external beam radiation (EBRT), brachytherapy and adjuvant chemotherapy. Of the 355 patients, 42% (146) were lost to follow-up while 18% (64) died during the two year period. 80.5% of patients presented with advanced stage IIB disease or above, with only 6.7% of patients receiving optimal combined EBRT, brachytherapy and adjuvant chemotherapy. Kaplan Meier survival curves projected two year survival at ,20%. Conclusion: Cervical cancer is preventable yet poverty, poor education, lack of cancer awareness coupled with an absence of regular screening programs, late patient presentation, sub-optimal diagnosis and treatments are major factors contributing to the alarmingly low survival rate of cervical cancer patients in Kenya. It is concluded that simple cost-effective changes in clinical practice could be introduced which would have a marked impact on patient survival in this setting.en_US
dc.description.sponsorshipTECHNICAL UNIVERSITY OF MOMBASAen_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleAnalysis of Factors Contributing to the Low Survival of Cervical Cancer Patients Undergoing Radiotherapy in Kenyaen_US
dc.typeArticleen_US


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