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dc.contributor.authorCojulun, Alicia Chang
dc.contributor.authorBustinduy, Amaya L
dc.contributor.authorSutherland, Laura J
dc.contributor.authorMungai, Peter L
dc.contributor.authorMutuku, Francis
dc.contributor.authorMuchiri, Eric
dc.contributor.authorKitron, Uriel
dc.contributor.authorKing, Charles H
dc.date.accessioned2021-06-04T09:27:47Z
dc.date.available2021-06-04T09:27:47Z
dc.date.issued2015
dc.identifier.urihttps://ir.tum.ac.ke/handle/123456789/17401
dc.description.abstractAnemia represents a substantial problem for children living in areas with limited resources and significant parasite burden. We performed a cross-sectional study of 254 Kenyan preschool- and early school-age children in a set ting endemic for multiple chronic parasitic infections to explore mechanisms of their anemia. Complete venous blood cell counts revealed a high prevalence of local childhood anemia (79%). Evaluating the potential links between low hemoglobin and socioeconomic factors, nutritional status, hemoglobinopathy, and/or parasite infection, we identified age < 9 years (odds ratio [OR]: 12.0, 95% confidence interval [CI]: 4.4, 33) and the presence of asymptomatic malaria infection (OR: 6.8, 95% CI: 2.1, 22) as the strongest independent correlates of having anemia. A total of 130/155 (84%) of anemic children with iron studies had evidence of iron-deficiency anemia (IDA), 16% had non-IDA; 50/52 of additionally tested anemic children met soluble transferrin-receptor (sTfR) criteria for combined anemia of inflammation (AI) with IDA. Children in the youngest age group had the greatest odds of iron deficiency (OR: 10.0, 95% CI: 3.9, 26). Although older children aged 9–11 years had less anemia, they had more detectable malaria, Schistosoma infection, hookworm, and proportionately more non-IDA. Anemia in this setting appears multifactorial such that chronic inflammation and iron deficiency need to be addressed together as part of integrated management of childhood anemiaen_US
dc.language.isoenen_US
dc.publisherThe American Society of Tropical Medicine and Hygieneen_US
dc.subjectAnemiaen_US
dc.subjectPolyparasitismen_US
dc.subjectCoastal Kenyaen_US
dc.titleAnemia among Children Exposed to Polyparasitism in Coastal Kenyaen_US
dc.typeArticleen_US


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