dc.contributor.author | Ndombi, Eric M | |
dc.contributor.author | Budambula, Valentine | |
dc.contributor.author | Webale, Mark K | |
dc.contributor.author | Musumba, Francis O | |
dc.contributor.author | Wesongah, Jesca O | |
dc.contributor.author | Mibei, Erick | |
dc.contributor.author | Ahmed, Aabid A | |
dc.contributor.author | Lihana, Raphael | |
dc.contributor.author | Were, Tom | |
dc.date.accessioned | 2024-02-20T13:35:12Z | |
dc.date.available | 2024-02-20T13:35:12Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Webale, M.K., Budambula, V., Lihana, R. et al. Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya. BMC Infect Dis 15, 299 (2015). https://doi.org/10.1186/s12879-015-1060-3 | en_US |
dc.identifier.issn | 2049-3614 | |
dc.identifier.uri | http://ir.tum.ac.ke/handle/123456789/17436 | |
dc.description | https://doi.org/10.1186/s12879-015-1060-3 | en_US |
dc.description.abstract | Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=−0.626; P<0.0001), hip (ρ=−0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=−0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs. | en_US |
dc.description.sponsorship | NRF | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.subject | adiponectin | en_US |
dc.subject | anthropometric markers of adiposity | en_US |
dc.subject | hepatitis C virus | en_US |
dc.subject | HIV | en_US |
dc.subject | anti-retroviral treatment | en_US |
dc.subject | injection drug users | en_US |
dc.title | Serum adiponectin in HIV-1 and hepatitis C virus mono- and coinfected Kenyan injection drug users | en_US |
dc.type | Article | en_US |